jeyakumar.chy's picture
Dr. Jeyakumar Kandasamy
Associate Professor
Department of Chemistry, IIT-BHU
jeyakumar.chy@iitbhu.ac.in
9794516773
Area of Interest: 
Organic Chemistry, Carbohydrate Chemistry

  1. Venkatesh, R.; Shankar, G.; Narayanan, A. C.; Modi, G.; Sabiah, S.; Kandasamy, J., Multicomponent Synthesis of S-Benzyl Dithiocarbamates from para-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer’s Disease. J. Org. Chem. 2022 (in press)
  2. Tiwari, V.; Murugan, K.; Sabiah, S.; Kandasamy, J., An Efficient and Direct Esterification of Uronic Acids Using H2SO4-SiO2 at Room Temperature. Tetrahedron Lett. 2022, 153852.
  3. Singh, S.; Sureshbabu, P.; Sabiah, S.; Kandasamy, J. Synthesis of N-Aryl α-Ketoamides, α-Ketoesters, α-Ketothioesters and Their Applications in Quinoxalinone Preparation. Asian J. Org. Chem. 2022, e202200122.
  4. Sureshbabu, P.; Azeez, S.; Pattanaik, K.; Sabiah, S.; Kandasamy, J., Synthesis of N‐Cbz Amides and Their Applications in the Transamidation Reactions at Room Temperature. Asian J. Org. Chem. 2022, e202200076
  5. Singh, A. K.; Venkatesh, R.; Kanaujiya, V. K.; Tiwari, V.; Kandasamy, J., Palladium-Catalyzed Reaction of Aryl Iodides and Glycal Enones: Application in the Preparation of Dapagliflozin Analogues. Eur. J. Org. Chem. 2022, In press
  6. Azeez, S.; Sureshbabu, P.; Sabiah, S.; Kandasamy, J., Controlled reduction of activated primary and secondary amides into aldehydes with diisobutylaluminum hydride. Org. Biomol. Chem. 2022, 20, 2048-2053. 
  7. Venkatesh,  R.;  Singh,  A.K.; Lee,  Y.R. Kandasamy, J.* Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium salts via regioselective Heck arylation at room temperature, Org. Biomol. Chem. 2021, 19, 7832-7837.
  8. Singh, S.; Popuri, S.; Junaid, Q.M.; Sabiah, S.; Kandasamy J.* Diversification of α-ketoamides via transamidation reactions with alkyl and benzyl amines at room temperature Org. Biomol. Chem. 2021, 19, 7134-7140.
  9. Baranwal,  S.;  Gupta, S .; Kandasamy, J.*  Selenium Dioxide Promoted alpha-Keto N-Acylation of Sulfoximines Under Mild Reaction Conditions,  Asian J. Org. Chem. 2021, 10, 1835-1845
  10. Chaudhary,  P.; Kandasamy,  J.; Macabeo,  A.P.G.;  Tamargo,  R.J.I.;  Lee,  Y.R.  Recent Advances and Strategies for the Transition‐Metal‐Catalyzed C−H Functionalization of N‐Nitrosoanilines Adv. Synth. Catal. 2021, 363, 2037-2060
  11. Singh, A. K.; Kanaujiya, V. K.; Tiwari, V.; Sabiah, S.; Kandasamy J.*  Development of Routes for the Stereoselective Preparation of β-Aryl-C-glycosides via C-1 Aryl Enones, Org. Lett., 2020, 22, 7650–7655. 
  12. Chauhan, S.; Verma, P.; Kandasamy, J.; Srivastava, V* A Practical Synthesis of 3‐Functionalized Coumarins from o‐Cresols and Active Methylene Compounds under Metal and Catalyst‐Free Conditions Using tert‐Butyl Hydrogen Peroxide, ChemistrySelect, 2020, 5, 9030.    
  13. Baranwal, S.; Kandasamy, J.;* Copper catalyzed N-arylation of sulfoximines with aryldiazonium salts in the presence of DABCO under mild conditions, Tetrahedron Lett. 2020, 61, 152079.     
  14. Azeez, S.;  Sureshbabu, P.; Sabiah, S.; Kandasamy, J.;* tert-Butyl nitrite catalyzed synthesis of benzimidazoles from o-phenylenediamine and aldehydes at room temperature, Tetrahedron Lett. 2020, 61, 151735.     
  15. Tiwari, V.; Badavath, V. N.; Singh, A. K.;  Kandasamy, J.; * Synthesis of photolabile group protected anomeric acetals and its application in carbohydrate synthesis with the assistance of continuous flow photo-reactor, J. Indian Chem. Soc., 2020, 97, 227-236.       
  16. Baranwal, S.; Gupta, S.; Sabiah, S.; Kandasamy, J.*  Molybdenumhexacarbonyl‐Mediated Imino‐Carbonylative Acylation of NH‐Sulfoximines with Aryl Iodides, Asian J. Org. Chem. 2019, 8, 2218-2227​
  17. Tiwari, V.; Singh, A. K.; Chaudhary, P.; Seeberger, P. H.; Kandasamy J.*  Synthesis of photolabile protecting group (PPG) protected uronic acid building blocks: applications in carbohydrate synthesis with the assistance of a continuous flow photoreactor, Org. Chem. Front., 2019, 6, 3859-3863.
  18. Sureshbabu, P.; Azeez, S.; Muniyappan, N.; Sabiah, S.; Kandasamy, J.;* Chemo-Selective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage Under Catalyst-free Condition,  J. Org. Chem., 2019, 84, 18, 11823-11838.
  19. Singh, A. K.; Venkatesh, R.; Kandasamy, J.* Palladium-Catalyzed One-Pot Stereospecific Synthesis of 2-Deoxy Aryl C-Glycosides from Glycals and Anilines in the Presence of tert- Butyl Nitrite, Synthesis, 2019, 51, 4215-4230.
  20. Allam, B. K.; Azeez, S.; Kandasamy, J.;* Nickel-Catalyzed Decarboxylative C–Si Bond Formation: A Regioselective Cross-Coupling Between Trialkyl Silanes and α,β-Unsaturated Carboxylic Acids, Appl. Organometal. Chem.,  2019, 33, e5192
  21. Gupta, S.; Baranwal,S.; Chaudhary, P.; Kandasamy, J.* Copper-promoted dehydrogenative cross-coupling reaction of dialkyl phosphites with sulfoximines, Org. Chem. Front., 2019, 6, 2260-2265.  
  22. Mishra, K. B.; Kandasamy, J.* Tris(Pentafluorophenyl)Borane‐Driven Stereoselective O‐Glycosylation with Glycal Donors under Mild Condition, Asian J. Org. Chem. 2019, 8, 549– 554
  23. Gupta, S.; Baranwal,S.; Muniyappan, N..; Sabiah, S.; Kandasamy, J.* Copper-catalyzed N-arylation of sulfoximines with arylboronic acid under mild Condition,  Synthesis , 2019, 51, 2171-2182
  24.  ​Sureshbabu, P.; Azeez, S.; Chaudhary, P.;   Kandasamy, J.*  tert-Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions, Org. Biomol. Chem. 2019 ,17, 845-850 
  25. Chaudhary, P.; Gupta, S.; Muniyappan, N..; Sabiah, S.; Kandasamy, J.* Regioselective Nitration of N‑Alkyl Anilines using tert-Butyl Nitrite under Mild Condition,  J. Org. Chem. 2019, 84, 104-119 .
  26. Geissner, A.; Reinhardt, A.; Rademacher, C.; Johannssen, T.; Monteiro, J.; Lepenies, B.; Thépaut, M.; Fieschi, F.; Mrázková, J.; Wimmerova, M.; Schuhmacher, F.; Götze, S.; Grünstein, D.; Guo, X.; Hahm, H. S.; Kandasamy J., Leonori, D.; Martin, C.; Parameswarappa, S. G.  Pasari, S.; Schlegel, M. K.; Tanaka, H.; Xiao, G.; Yang, Y.; Pereira, C. L. Anish , C.;  Seeberger, P. H. A microbe-focused glycan array screening platform, Proc. Natl. Acad. Sci. (USA), 2019, 116, 1958-1967.
  27. Azeez, S.; Chaudhary, P.;  Sureshbabu, P.;  Sabiah, S.; Kandasamy, J.* tert-Butyl nitrite mediated nitrogen transfer reactions: Synthesis of benzotriazoles and azides at room temperature,  Org. Biomol. Chem. 2018, 16, 8280-8285.  
  28. Azeez, S.; Chaudhary, P.;  Sureshbabu, P.;  Sabiah, S.; Kandasamy, J.* Potassium persulfate promoted N-nitrosation of secondary and tertiary amines with nitromethane under mild condition, Asian J. Org. Chem. 2018, 7, 2113-2119.
  29. Singh, A. K.; Kandasamy J.*  Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature, Org. Biomol. Chem. 2018, 16, 5107-5112.  
  30. Tiwari, V.; Badavath,V. N.; Singh, A. K.; Kandasamy J.*  A highly efficient TEMPO mediated oxidation of sugar primary alcohols into uronic acids using 1-chloro-1,2-benziodoxol-3(1H)-one at room temperature, Tetrahedron Lett., 2018, 59, 2511-2514.
  31. Mishra, K.B.; Singh, A. K.; Kandasamy J.* Tris(pentafluorophenyl)borane Promoted Stereoselective Glycosylation with Glycosyl Trichloroacetimidates under Mild Condition, J. Org. Chem. 2018, 83, 4204-4212.
  32. Chauhan, S.; Chaudhary, P.; Singh, A. K.; Verma, P.; Srivastava, V.* ; Kandasamy, J.* tert-Butyl nitrite induced radical dimerization of primary thioamides and selenoamides at room temperature, Tetrahedron. Lett., 2018, 59, 272–276.
  33. Chaudhary, P.; Korde, R.; Gupta, S.; Sureshbabu, P.; Sabiah, S.;, Kandasamy, J.* An efficient metal-free method for the denitrosation of aryl n-nitrosamines at room temperature, Adv. Synth. Catal. 2018, 360, 556–561.
  34. Gupta, S.; Chaudhary, P.; Muniyappan, N..;  Sabiah, S.;  Kandasamy, J.* Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions, Org. Biomol. Chem. 2017, 15, 8493-8498.
  35. Singh, A. K.; Tiwari, V.; Mishra, K. B., Gupta S. and Kandasamy J.  Urea-hydrogen peroxide prompted selective and controlled oxidation of thioglycosides into Sulfoxides and Sulfones, Beilstein J. Org. Chem., 2017, 13, 1139–1144.
  36. Gupta, S.; Sureshbabu, P.; Singh, A. K.;  Sabiah, S.;  Kandasamy, J.* Deoxygenation of tertiary amine N-oxides under metal free condition using phenylboronic acid, Tetrahedron. Lett., 2017, 58, 909-913.
  37. Chaudhary, P.; Gupta, S.; Popuri, S.; Sabiah S.; Kandasamy, J.* A metal free reduction of aryl-N-nitrosamines to corresponding hydrazines using sustainable reductant thiourea dioxide, Green Chem., 2016, 18, 6215–6221.
  38. Gupta, S.; Chaudhary, P.; Srivastava, V.; Kandasamy, J.* A chemoselective ipso-hydroxylation of arylboronic acids using urea-hydrogen peroxide under catalyst free condition,  Tetrahedron. Lett., 2016, 57, 2506–2510.
  39. Chaudhary, P.; Gupta, S.; Muniyappan, N.; Sabiah S.; Kandasamy, J.* An efficient synthesis of N-nitrosamines under solvent, metal and acid free conditions using tert-butyl nitrite, Green Chem., 2016 18, 2323-2330.
  40. Gupta, S.; Chaudhary, P.; Seva L.; Sabiah S.; Kandasamy, J.*  Bio-based green solvent for the catalyst free oxidation of arylboronic acids into phenols. RSC Adv., 2015, 5, 89133–89138.
  41. Nonaka, M.; Bao, X. Matsumura, F.; Götze, S.; Kandasamy, J.; Broide, D. H.; Nakayama, J.; Seeberger, P. H.; Fukuda M. “An unusual di-sulfated Iduronic acid attenuates asthmatic response in mice by interfering chemokine-heparan sulfate-mediated T cell recruitment” Proc. Natl. Acad. Sci. (USA), 2014, 111, 8173-8178.      
  42. Hurevich, M.;  Kandasamy, J.; Ponnappa, B. M.; Kopetzki,  D.; McQuade,  T.; Seeberger, P. H. “Continuous Photochemical Cleavage of Linkers for Solid Phase Synthesis”, Org. Lett., 2014, 16, 1794–1797.   
  43. Gunn, G.; Dai, Y.; Du, M.; Belakhov, V.; Kandasamy, J.; Schoeb, T.;  Baasov, T.; Bedwell,  D. “Long-Term Nonsense Suppression Therapy Moderates MPS I-H Disease Progression” Molecular Genetics and Metabolism, 2014, 111, 374-381. 
  44. Kandasamy, J.; Schuhmacher, F.; Hahm, H.S.; Klein, J. C.; Seeberger, P. H. “Modular automated solid phase synthesis of dermatan sulfate oligosaccharides” Chem. Commun., 2014, 50, 1875-1877 . 
  45. Kandasamy, J.; Hurevich, M.; Seeberger, P. H. “Automated solid phase synthesis of oligoarabinofuranosides”. Chem. Commun., 2013, 49, 4453-4455. (Cover Page)
  46. Keeling, K.; Wang, D.; Dai, Y.; Srinivasan, M.; Chenna, B.; Clark, J.; Belakhov, V.; Kandasamy, J.; Velu, S.; Baasov, T.; Bedwell, D. “Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression”. PLoS One, 2013, 8, e60478.
  47. Shalev, M.; Kandasamy, J.; Skalka, N.; Belakhov, V.; Rosin-Arbesfeld, R.; Baasov, T. “Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH for the treatment of genetic diseases in biological samples”. J. Pharmaceut. Biomed. Anal. 2013, 75, 33-40.
  48. Kandasamy, J.; Glikin, D.; Shulman, E.; Shapira, K.; Shavit, M.; Belakhov, V.; Baasov, T. “Increased selectivity towards cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: A strategy for treatment of genetic diseases caused by nonsense mutations”. J. Med. Chem. 2012, 55, 10630–10643.
  49. Wang, D.; Belakhov, V.; Kandasamy, J.; Baasov, T.; Li, S-C.; Li, Y-T.; Bedwell, D. M.; Keeling K. M. “The designer aminoglycoside NB84 significantly attenuates biochemical defects associates with MPS I-H in the Idua-W392X mouse”. Molecular Genetics and Metabolism, 2012, 105, 116–125.
  50. Kandasamy, J.; Glikin, D.; Belakhov, V.; Baasov, T. “Repairing faulty genes by aminoglycosides: Identification of new pharmacophore with enhanced suppression of diseases-causing nonsense mutations”. Med. Chem. Commun., 2011, 2, 165-171 (Highlighted in "RSC-Chemistry World" as HOT paper).
  51. Pokrovskaya, V.; Nudelman, I.; Kandasamy, J.; Baasov, T. “Aminoglycosides: Redesign strategies for improved antibiotics and compounds for treatment of human genetic diseases”. Methods in Enzymology, 2010, 21, 437-462.
  52. Jeyakumar, K.; Chakravarthy, R. D.; Chand, D. K. “Simple and efficient method for the oxidation of sulfides to sulfones using hydrogen peroxide and a Mo(VI) based catalyst”. Catal. Commun. 2009, 10, 1948-1941.
  53. Jeyakumar, K.; Chand, D. K. “Application of molybdenum(VI) dichloride dioxide (MoO2Cl2) in organic transformations”. J. Chem. Sci. 2009, 121, 111-123.  [Highlighted in Cover Page].
  54. Jeyakumar, K.; Chand, D. K. “Molybdenum(VI) dichloride dioxide catalyzed oxidation of β-hydroxycarbonyls to α-bromo 1,3-dicarbonyls by N-bromosuccinimide”. Synthesis, 2009, 306-310.
  55. Jeyakumar, K.; Chand, D. K. “Molybdenum(VI)/copper(II)- An efficient bimetallic catalyst for aerobic oxidation of   alcohols”. Open Catal. J. 2008, 1, 6-11. [Invited article by the editor].
  56. Jeyakumar, K.; Chand, D. K. “Molybdenum(VI) dichloride dioxide catalyzed synthesis  of β-ketoesters by C–H insertion of ethyl diazoacetate into aldehydes”. Synthesis, 2008, 1685-1687.
  57. Jeyakumar, K.; Chand, D. K. “Ring opening reactions of epoxides catalyzed by molybdenum(VI) dichloride dioxide”. Synthesis, 2008, 807-819.
  58. Jeyakumar, K.; Chand, D. K.  “Copper perchlorate: Efficient acetylation catalyst under solvent free conditions”. J. Mol. Catal. A: Chem. 2006, 255, 275-282.
  59. Jeyakumar, K.; Chand, D. K. “Selective oxidation of sulfides to sulfoxides and sulfones at room temperature using H2O2 and a Mo(VI) salt as catalyst”. Tetrahedron Lett., 2006, 47, 4573-4576.  (> 85 times cited) 
  60. Jeyakumar, K.; Chand, D. K. “Aerobic oxidation of benzyl alcohols by Mo (VI) compounds”. Appl. Organometal. Chem. 2006, 20, 840-844.
  61. Chand, D. K.; Manivannan, R.; Sahoo, H. S.; Jeyakumar, K. “Self-assembly by ligand-exchange reactions”. Eur. J. Inorg. Chem. 2005, 3346–335   
 
BOOK CHAPTER
  1. Hurevich, M.; Kandasamy, J.; Seeberger, P. H. “Automated Techniques for Carbohydrate Synthesis”. in Glycochemical Synthesis: Strategies and Applications, 2016, (edited by Prof. Shang-Cheng Hung) (Publisher: Wiley)
  2. Kandasamy J.; Sabiah, S. “Carbohydrates in drug discovery:  Insights into sulfated marine polysaccharides”. in Marine Glycobiology: Principles and Applications, 2016 (Edited by Prof. Se-Kwon Kim), CRC press Taylor & Francis, USA.

PATENT

  1. Baasov, T.; Glikin, D.; Kandasamy, J.; Belakhov, V. “Preparation of aminoglycosides and uses thereof in treating genetic disorders and as antibacterial agents”. PCT Int. Appl. (2012), WO 2012066546 A1 20120524.

 

 

S. No. Name of the Student Year of registration Year of completion/progress Title of Thesis
1. Dr. Surabhi Gupta June 2014 Completed 2018
 		 Applications of Boronic Acids As a Reagent and Starting Material In Organic Synthesis
2. Dr. Priyanka Chaudhary June 2014 Completed 2018

 

 Synthesis and Applications of N-Nitrosamines in Organic Syntheses
3. Mr. Adesh Kumar Singh 2015 Completed 2020 New glycosylation methods for carbohydrate synthesis
4. Ms. Varsha Tiwari 2016 Submitted 2022 Syntheis and applications of uronic acids
5. Ms. Sadaf Siddiqui 2016 Completed 2021 Carboxylic acid as surrogates for organic synthesis
6 Mr. Sidharth Branwal 2017 Completed 2021 Sulfoximine Synthesis and applications
7 Mr. Vimleshkumar 2018 In progress Novel glycosylation methods for carbohydrate synthesis
8 Ms. Shweta Singh 2018 In progress Reaction Methodology
9 Mr. Venkatesh 2019 In progress Applications of aryl diazonium salts

10                  Mr. Nitin Kumar               2021                In progress                                Diazocompounds
11                  Ms. Aswathi                     2021               In progress                                 Carbohydrates 

 

Academic Profile

  • Ph.D. [with Prof. Dillip K. Chand]: IIT-Madras [2004-2008]
  • M.Sc.: University of Madras. [2003]
  • B.Sc.: A. A. G. A. College, Namakkal. [2000]

Professional Profile

  • Associate Professor: Indian Institute of Technology (Banaras Hindu University) Varanasi [Aug 2019-Till date]
  • Assistant Professor: Indian Institute of Technology (Banaras Hindu University) Varanasi [June 2014-Aug 2019]
  • Post Doctoral Fellow [with Prof. Timor Baasov]: Technion-Israel Institute of Technology, Haifa, Israel [2008-2011]
  • Post Doctoral Fellow [with Prof. Peter. H. Seeberger]: Max Planck Institute of Colloids and Interfaces (MPIKG), Berlin, Germany [2012-2014]
  • Euroglycoscience Award: European young investigator workshop-France. 2011
  • Schulich Postdoctoral Fellowship (Technion, Israel): -Oct. 2008 -Sep-2011
  • Council of Scientific and Industrial Research (CSIR):- 2004 (CSIR-JRF&SRF)
  • Graduate Aptitude Test in Engineering (GATE): -2004 (95.01 percentile)
  • Topper in Comprehensive Exam in IITMadras-2005