Dr. Jeyakumar Kandasamy
Associate Professor
Department of Chemistry, IIT-BHU
jeyakumar.chy@iitbhu.ac.in
9794516773
Area of Interest:
Organic Chemistry, Carbohydrate Chemistry
- Venkatesh, R.; Shankar, G.; Narayanan, A. C.; Modi, G.; Sabiah, S.; Kandasamy, J., Multicomponent Synthesis of S-Benzyl Dithiocarbamates from para-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer’s Disease. J. Org. Chem. 2022 (in press)
- Tiwari, V.; Murugan, K.; Sabiah, S.; Kandasamy, J., An Efficient and Direct Esterification of Uronic Acids Using H2SO4-SiO2 at Room Temperature. Tetrahedron Lett. 2022, 153852.
- Singh, S.; Sureshbabu, P.; Sabiah, S.; Kandasamy, J. Synthesis of N-Aryl α-Ketoamides, α-Ketoesters, α-Ketothioesters and Their Applications in Quinoxalinone Preparation. Asian J. Org. Chem. 2022, e202200122.
- Sureshbabu, P.; Azeez, S.; Pattanaik, K.; Sabiah, S.; Kandasamy, J., Synthesis of N‐Cbz Amides and Their Applications in the Transamidation Reactions at Room Temperature. Asian J. Org. Chem. 2022, e202200076
- Singh, A. K.; Venkatesh, R.; Kanaujiya, V. K.; Tiwari, V.; Kandasamy, J., Palladium-Catalyzed Reaction of Aryl Iodides and Glycal Enones: Application in the Preparation of Dapagliflozin Analogues. Eur. J. Org. Chem. 2022, In press
- Azeez, S.; Sureshbabu, P.; Sabiah, S.; Kandasamy, J., Controlled reduction of activated primary and secondary amides into aldehydes with diisobutylaluminum hydride. Org. Biomol. Chem. 2022, 20, 2048-2053.
- Venkatesh, R.; Singh, A.K.; Lee, Y.R. Kandasamy, J.* Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium salts via regioselective Heck arylation at room temperature, Org. Biomol. Chem. 2021, 19, 7832-7837.
- Singh, S.; Popuri, S.; Junaid, Q.M.; Sabiah, S.; Kandasamy J.* Diversification of α-ketoamides via transamidation reactions with alkyl and benzyl amines at room temperature Org. Biomol. Chem. 2021, 19, 7134-7140.
- Baranwal, S.; Gupta, S .; Kandasamy, J.* Selenium Dioxide Promoted alpha-Keto N-Acylation of Sulfoximines Under Mild Reaction Conditions, Asian J. Org. Chem. 2021, 10, 1835-1845
- Chaudhary, P.; Kandasamy, J.; Macabeo, A.P.G.; Tamargo, R.J.I.; Lee, Y.R. Recent Advances and Strategies for the Transition‐Metal‐Catalyzed C−H Functionalization of N‐Nitrosoanilines Adv. Synth. Catal. 2021, 363, 2037-2060
- Singh, A. K.; Kanaujiya, V. K.; Tiwari, V.; Sabiah, S.; Kandasamy J.* Development of Routes for the Stereoselective Preparation of β-Aryl-C-glycosides via C-1 Aryl Enones, Org. Lett., 2020, 22, 7650–7655.
- Chauhan, S.; Verma, P.; Kandasamy, J.; Srivastava, V* A Practical Synthesis of 3‐Functionalized Coumarins from o‐Cresols and Active Methylene Compounds under Metal and Catalyst‐Free Conditions Using tert‐Butyl Hydrogen Peroxide, ChemistrySelect, 2020, 5, 9030.
- Baranwal, S.; Kandasamy, J.;* Copper catalyzed N-arylation of sulfoximines with aryldiazonium salts in the presence of DABCO under mild conditions, Tetrahedron Lett. 2020, 61, 152079.
- Azeez, S.; Sureshbabu, P.; Sabiah, S.; Kandasamy, J.;* tert-Butyl nitrite catalyzed synthesis of benzimidazoles from o-phenylenediamine and aldehydes at room temperature, Tetrahedron Lett. 2020, 61, 151735.
- Tiwari, V.; Badavath, V. N.; Singh, A. K.; Kandasamy, J.; * Synthesis of photolabile group protected anomeric acetals and its application in carbohydrate synthesis with the assistance of continuous flow photo-reactor, J. Indian Chem. Soc., 2020, 97, 227-236.
- Baranwal, S.; Gupta, S.; Sabiah, S.; Kandasamy, J.* Molybdenumhexacarbonyl‐Mediated Imino‐Carbonylative Acylation of NH‐Sulfoximines with Aryl Iodides, Asian J. Org. Chem. 2019, 8, 2218-2227
- Tiwari, V.; Singh, A. K.; Chaudhary, P.; Seeberger, P. H.; Kandasamy J.* Synthesis of photolabile protecting group (PPG) protected uronic acid building blocks: applications in carbohydrate synthesis with the assistance of a continuous flow photoreactor, Org. Chem. Front., 2019, 6, 3859-3863.
- Sureshbabu, P.; Azeez, S.; Muniyappan, N.; Sabiah, S.; Kandasamy, J.;* Chemo-Selective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage Under Catalyst-free Condition, J. Org. Chem., 2019, 84, 18, 11823-11838.
- Singh, A. K.; Venkatesh, R.; Kandasamy, J.* Palladium-Catalyzed One-Pot Stereospecific Synthesis of 2-Deoxy Aryl C-Glycosides from Glycals and Anilines in the Presence of tert- Butyl Nitrite, Synthesis, 2019, 51, 4215-4230.
- Allam, B. K.; Azeez, S.; Kandasamy, J.;* Nickel-Catalyzed Decarboxylative C–Si Bond Formation: A Regioselective Cross-Coupling Between Trialkyl Silanes and α,β-Unsaturated Carboxylic Acids, Appl. Organometal. Chem., 2019, 33, e5192
- Gupta, S.; Baranwal,S.; Chaudhary, P.; Kandasamy, J.* Copper-promoted dehydrogenative cross-coupling reaction of dialkyl phosphites with sulfoximines, Org. Chem. Front., 2019, 6, 2260-2265.
- Mishra, K. B.; Kandasamy, J.* Tris(Pentafluorophenyl)Borane‐Driven Stereoselective O‐Glycosylation with Glycal Donors under Mild Condition, Asian J. Org. Chem. 2019, 8, 549– 554
- Gupta, S.; Baranwal,S.; Muniyappan, N..; Sabiah, S.; Kandasamy, J.* Copper-catalyzed N-arylation of sulfoximines with arylboronic acid under mild Condition, Synthesis , 2019, 51, 2171-2182
- Sureshbabu, P.; Azeez, S.; Chaudhary, P.; Kandasamy, J.* tert-Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions, Org. Biomol. Chem. 2019 ,17, 845-850
- Chaudhary, P.; Gupta, S.; Muniyappan, N..; Sabiah, S.; Kandasamy, J.* Regioselective Nitration of N‑Alkyl Anilines using tert-Butyl Nitrite under Mild Condition, J. Org. Chem. 2019, 84, 104-119 .
- Geissner, A.; Reinhardt, A.; Rademacher, C.; Johannssen, T.; Monteiro, J.; Lepenies, B.; Thépaut, M.; Fieschi, F.; Mrázková, J.; Wimmerova, M.; Schuhmacher, F.; Götze, S.; Grünstein, D.; Guo, X.; Hahm, H. S.; Kandasamy J., Leonori, D.; Martin, C.; Parameswarappa, S. G. Pasari, S.; Schlegel, M. K.; Tanaka, H.; Xiao, G.; Yang, Y.; Pereira, C. L. Anish , C.; Seeberger, P. H. A microbe-focused glycan array screening platform, Proc. Natl. Acad. Sci. (USA), 2019, 116, 1958-1967.
- Azeez, S.; Chaudhary, P.; Sureshbabu, P.; Sabiah, S.; Kandasamy, J.* tert-Butyl nitrite mediated nitrogen transfer reactions: Synthesis of benzotriazoles and azides at room temperature, Org. Biomol. Chem. 2018, 16, 8280-8285.
- Azeez, S.; Chaudhary, P.; Sureshbabu, P.; Sabiah, S.; Kandasamy, J.* Potassium persulfate promoted N-nitrosation of secondary and tertiary amines with nitromethane under mild condition, Asian J. Org. Chem. 2018, 7, 2113-2119.
- Singh, A. K.; Kandasamy J.* Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature, Org. Biomol. Chem. 2018, 16, 5107-5112.
- Tiwari, V.; Badavath,V. N.; Singh, A. K.; Kandasamy J.* A highly efficient TEMPO mediated oxidation of sugar primary alcohols into uronic acids using 1-chloro-1,2-benziodoxol-3(1H)-one at room temperature, Tetrahedron Lett., 2018, 59, 2511-2514.
- Mishra, K.B.; Singh, A. K.; Kandasamy J.* Tris(pentafluorophenyl)borane Promoted Stereoselective Glycosylation with Glycosyl Trichloroacetimidates under Mild Condition, J. Org. Chem. 2018, 83, 4204-4212.
- Chauhan, S.; Chaudhary, P.; Singh, A. K.; Verma, P.; Srivastava, V.* ; Kandasamy, J.* tert-Butyl nitrite induced radical dimerization of primary thioamides and selenoamides at room temperature, Tetrahedron. Lett., 2018, 59, 272–276.
- Chaudhary, P.; Korde, R.; Gupta, S.; Sureshbabu, P.; Sabiah, S.;, Kandasamy, J.* An efficient metal-free method for the denitrosation of aryl n-nitrosamines at room temperature, Adv. Synth. Catal. 2018, 360, 556–561.
- Gupta, S.; Chaudhary, P.; Muniyappan, N..; Sabiah, S.; Kandasamy, J.* Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions, Org. Biomol. Chem. 2017, 15, 8493-8498.
- Singh, A. K.; Tiwari, V.; Mishra, K. B., Gupta S. and Kandasamy J. Urea-hydrogen peroxide prompted selective and controlled oxidation of thioglycosides into Sulfoxides and Sulfones, Beilstein J. Org. Chem., 2017, 13, 1139–1144.
- Gupta, S.; Sureshbabu, P.; Singh, A. K.; Sabiah, S.; Kandasamy, J.* Deoxygenation of tertiary amine N-oxides under metal free condition using phenylboronic acid, Tetrahedron. Lett., 2017, 58, 909-913.
- Chaudhary, P.; Gupta, S.; Popuri, S.; Sabiah S.; Kandasamy, J.* A metal free reduction of aryl-N-nitrosamines to corresponding hydrazines using sustainable reductant thiourea dioxide, Green Chem., 2016, 18, 6215–6221.
- Gupta, S.; Chaudhary, P.; Srivastava, V.; Kandasamy, J.* A chemoselective ipso-hydroxylation of arylboronic acids using urea-hydrogen peroxide under catalyst free condition, Tetrahedron. Lett., 2016, 57, 2506–2510.
- Chaudhary, P.; Gupta, S.; Muniyappan, N.; Sabiah S.; Kandasamy, J.* An efficient synthesis of N-nitrosamines under solvent, metal and acid free conditions using tert-butyl nitrite, Green Chem., 2016 18, 2323-2330.
- Gupta, S.; Chaudhary, P.; Seva L.; Sabiah S.; Kandasamy, J.* Bio-based green solvent for the catalyst free oxidation of arylboronic acids into phenols. RSC Adv., 2015, 5, 89133–89138.
- Nonaka, M.; Bao, X. Matsumura, F.; Götze, S.; Kandasamy, J.; Broide, D. H.; Nakayama, J.; Seeberger, P. H.; Fukuda M. “An unusual di-sulfated Iduronic acid attenuates asthmatic response in mice by interfering chemokine-heparan sulfate-mediated T cell recruitment” Proc. Natl. Acad. Sci. (USA), 2014, 111, 8173-8178.
- Hurevich, M.; Kandasamy, J.; Ponnappa, B. M.; Kopetzki, D.; McQuade, T.; Seeberger, P. H. “Continuous Photochemical Cleavage of Linkers for Solid Phase Synthesis”, Org. Lett., 2014, 16, 1794–1797.
- Gunn, G.; Dai, Y.; Du, M.; Belakhov, V.; Kandasamy, J.; Schoeb, T.; Baasov, T.; Bedwell, D. “Long-Term Nonsense Suppression Therapy Moderates MPS I-H Disease Progression” Molecular Genetics and Metabolism, 2014, 111, 374-381.
- Kandasamy, J.; Schuhmacher, F.; Hahm, H.S.; Klein, J. C.; Seeberger, P. H. “Modular automated solid phase synthesis of dermatan sulfate oligosaccharides” Chem. Commun., 2014, 50, 1875-1877 .
- Kandasamy, J.; Hurevich, M.; Seeberger, P. H. “Automated solid phase synthesis of oligoarabinofuranosides”. Chem. Commun., 2013, 49, 4453-4455. (Cover Page)
- Keeling, K.; Wang, D.; Dai, Y.; Srinivasan, M.; Chenna, B.; Clark, J.; Belakhov, V.; Kandasamy, J.; Velu, S.; Baasov, T.; Bedwell, D. “Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression”. PLoS One, 2013, 8, e60478.
- Shalev, M.; Kandasamy, J.; Skalka, N.; Belakhov, V.; Rosin-Arbesfeld, R.; Baasov, T. “Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH for the treatment of genetic diseases in biological samples”. J. Pharmaceut. Biomed. Anal. 2013, 75, 33-40.
- Kandasamy, J.; Glikin, D.; Shulman, E.; Shapira, K.; Shavit, M.; Belakhov, V.; Baasov, T. “Increased selectivity towards cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: A strategy for treatment of genetic diseases caused by nonsense mutations”. J. Med. Chem. 2012, 55, 10630–10643.
- Wang, D.; Belakhov, V.; Kandasamy, J.; Baasov, T.; Li, S-C.; Li, Y-T.; Bedwell, D. M.; Keeling K. M. “The designer aminoglycoside NB84 significantly attenuates biochemical defects associates with MPS I-H in the Idua-W392X mouse”. Molecular Genetics and Metabolism, 2012, 105, 116–125.
- Kandasamy, J.; Glikin, D.; Belakhov, V.; Baasov, T. “Repairing faulty genes by aminoglycosides: Identification of new pharmacophore with enhanced suppression of diseases-causing nonsense mutations”. Med. Chem. Commun., 2011, 2, 165-171 (Highlighted in "RSC-Chemistry World" as HOT paper).
- Pokrovskaya, V.; Nudelman, I.; Kandasamy, J.; Baasov, T. “Aminoglycosides: Redesign strategies for improved antibiotics and compounds for treatment of human genetic diseases”. Methods in Enzymology, 2010, 21, 437-462.
- Jeyakumar, K.; Chakravarthy, R. D.; Chand, D. K. “Simple and efficient method for the oxidation of sulfides to sulfones using hydrogen peroxide and a Mo(VI) based catalyst”. Catal. Commun. 2009, 10, 1948-1941.
- Jeyakumar, K.; Chand, D. K. “Application of molybdenum(VI) dichloride dioxide (MoO2Cl2) in organic transformations”. J. Chem. Sci. 2009, 121, 111-123. [Highlighted in Cover Page].
- Jeyakumar, K.; Chand, D. K. “Molybdenum(VI) dichloride dioxide catalyzed oxidation of β-hydroxycarbonyls to α-bromo 1,3-dicarbonyls by N-bromosuccinimide”. Synthesis, 2009, 306-310.
- Jeyakumar, K.; Chand, D. K. “Molybdenum(VI)/copper(II)- An efficient bimetallic catalyst for aerobic oxidation of alcohols”. Open Catal. J. 2008, 1, 6-11. [Invited article by the editor].
- Jeyakumar, K.; Chand, D. K. “Molybdenum(VI) dichloride dioxide catalyzed synthesis of β-ketoesters by C–H insertion of ethyl diazoacetate into aldehydes”. Synthesis, 2008, 1685-1687.
- Jeyakumar, K.; Chand, D. K. “Ring opening reactions of epoxides catalyzed by molybdenum(VI) dichloride dioxide”. Synthesis, 2008, 807-819.
- Jeyakumar, K.; Chand, D. K. “Copper perchlorate: Efficient acetylation catalyst under solvent free conditions”. J. Mol. Catal. A: Chem. 2006, 255, 275-282.
- Jeyakumar, K.; Chand, D. K. “Selective oxidation of sulfides to sulfoxides and sulfones at room temperature using H2O2 and a Mo(VI) salt as catalyst”. Tetrahedron Lett., 2006, 47, 4573-4576. (> 85 times cited)
- Jeyakumar, K.; Chand, D. K. “Aerobic oxidation of benzyl alcohols by Mo (VI) compounds”. Appl. Organometal. Chem. 2006, 20, 840-844.
- Chand, D. K.; Manivannan, R.; Sahoo, H. S.; Jeyakumar, K. “Self-assembly by ligand-exchange reactions”. Eur. J. Inorg. Chem. 2005, 3346–335
BOOK CHAPTER
- Hurevich, M.; Kandasamy, J.; Seeberger, P. H. “Automated Techniques for Carbohydrate Synthesis”. in Glycochemical Synthesis: Strategies and Applications, 2016, (edited by Prof. Shang-Cheng Hung) (Publisher: Wiley)
- Kandasamy J.; Sabiah, S. “Carbohydrates in drug discovery: Insights into sulfated marine polysaccharides”. in Marine Glycobiology: Principles and Applications, 2016 (Edited by Prof. Se-Kwon Kim), CRC press Taylor & Francis, USA.
PATENT
- Baasov, T.; Glikin, D.; Kandasamy, J.; Belakhov, V. “Preparation of aminoglycosides and uses thereof in treating genetic disorders and as antibacterial agents”. PCT Int. Appl. (2012), WO 2012066546 A1 20120524.
S. No. | Name of the Student | Year of registration | Year of completion/progress | Title of Thesis |
1. | Dr. Surabhi Gupta | June 2014 | Completed 2018 |
Applications of Boronic Acids As a Reagent and Starting Material In Organic Synthesis |
2. | Dr. Priyanka Chaudhary | June 2014 | Completed 2018
|
Synthesis and Applications of N-Nitrosamines in Organic Syntheses |
3. | Mr. Adesh Kumar Singh | 2015 | Completed 2020 | New glycosylation methods for carbohydrate synthesis |
4. | Ms. Varsha Tiwari | 2016 | Submitted 2022 | Syntheis and applications of uronic acids |
5. | Ms. Sadaf Siddiqui | 2016 | Completed 2021 | Carboxylic acid as surrogates for organic synthesis |
6 | Mr. Sidharth Branwal | 2017 | Completed 2021 | Sulfoximine Synthesis and applications |
7 | Mr. Vimleshkumar | 2018 | In progress | Novel glycosylation methods for carbohydrate synthesis |
8 | Ms. Shweta Singh | 2018 | In progress | Reaction Methodology |
9 | Mr. Venkatesh | 2019 | In progress | Applications of aryl diazonium salts |
10 Mr. Nitin Kumar 2021 In progress Diazocompounds
11 Ms. Aswathi 2021 In progress Carbohydrates
Academic Profile
- Ph.D. [with Prof. Dillip K. Chand]: IIT-Madras [2004-2008]
- M.Sc.: University of Madras. [2003]
- B.Sc.: A. A. G. A. College, Namakkal. [2000]
Professional Profile
- Associate Professor: Indian Institute of Technology (Banaras Hindu University) Varanasi [Aug 2019-Till date]
- Assistant Professor: Indian Institute of Technology (Banaras Hindu University) Varanasi [June 2014-Aug 2019]
- Post Doctoral Fellow [with Prof. Timor Baasov]: Technion-Israel Institute of Technology, Haifa, Israel [2008-2011]
- Post Doctoral Fellow [with Prof. Peter. H. Seeberger]: Max Planck Institute of Colloids and Interfaces (MPIKG), Berlin, Germany [2012-2014]
- Euroglycoscience Award: European young investigator workshop-France. 2011
- Schulich Postdoctoral Fellowship (Technion, Israel): -Oct. 2008 -Sep-2011
- Council of Scientific and Industrial Research (CSIR):- 2004 (CSIR-JRF&SRF)
- Graduate Aptitude Test in Engineering (GATE): -2004 (95.01 percentile)
- Topper in Comprehensive Exam in IITMadras-2005