Dr. Pandeeswar Makam
Assistant Professor
Department of Chemistry, Indian Institute of Technology (BHU)
Varanasi, Uttar Pradesh, India-221005
E-mail: pandeeswar.chy@itbhu.ac.in

Research Interest: Our research is inspired by biological systems and focuses on integrating chemistry, biology, and materials sciences to create unique eco-friendly multifunctional nanomaterials that address scientific concerns in energy, environment, and health care.

Our research projects offer students significant knowledge and methodologies in organic synthesis as well as spectroscopic and microscopic characterization.

Selected Publications

• Makam, P.*; Yamijala, S. S. R. K. C.; Bhadram, V. S.; Shimon, L. J. W.; Wong, B. M.*; Gazit, E.* Single Amino Acid Bionanozyme for Environmental Remediation. Nat. Commun. 2022, 13, 1505. (Impact Factor: 17.69)

• ​Makam, P.; Yamijala, S. S. R. K. C., Tao, K.;   Shimon, L. J.W.; Eisenberg, D. S.; Sawaya, M. R.; Wong, B. M.; Gazit, E. Nonproteinaceous Hydrolase Comprised of Phenylalanine Metallo-Supramolecular Amyloid-like Structure. Nat. Catal. 2019, 2 (11), 977-985. (Impact Factor: 40.71). 

• Tao, K.; Makam, P.; Aizen, R.; Gazit, E. Self-Assembling Peptide Semiconductors. Science 2017, 358 (6365), eaam9756 (Impact Factor: 63.71)

• ​Makam, P.; Gazit, E. Minimalistic Peptide Supramolecular Co-Assembly: Expanding the Conformational Space for Nanotechnology. Chem. Soc. Rev. 2018, 47 (10), 3406–3420 (Impact Factor: 60.61).

• Makam, P.; Senanayak, S. P.; Narayan, K. S.; Govindaraju, T. Multi-Stimuli-Responsive Charge-Transfer Hydrogel for Room-Temperature Organic Ferroelectric Thin-Film Devices. J. Am. Chem. Soc. 2016, 138 (26), 8259–8268 (Impact Factor: 16.38).

Professional Experience:
 

• Assistant Professor: Indian Institute of Technology (BHU), Varanasi, India (12/2020 – Present) 

• Postdoctoral Research Fellow: Tel Aviv University, Israel with Prof. Ehud Gazit (10/2016 – 11/2020)

• Research Associate: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), India with Prof. T. Govindaraju (04/2016 – 10/2016)

Educational Background:
 

• Ph.D.:  New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), India with Prof. T. Govindaraju (2016)

• M.S.: Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), India (2011)

• B.Sc.: Bhavan's New Science College, Osmania University, Telangana, India (2007)

• Makam, P.*; Yamijala, S. S. R. K. C.; Bhadram, V. S.; Shimon, L. J. W.; Wong, B. M.*; Gazit, E.* Single Amino Acid Bionanozyme for Environmental Remediation. Nat. Commun. 2022, 13, 1505. (Impact Factor: 17.69)

• Ji, W.; Tang, Y.; Makam, P.; Yao, Y.; Jiao, R.; Cai, K.; Wei, G.; Gazit, E. Expanding the Structural Diversity and Functional Scope of Diphenylalanine-Based Peptide Architectures by Hierarchical Coassembly. J. Am. Chem. Soc. 2021, 143, 17633-17645. (Impact Factor: 16.38)

• Chen, Y.; Yang, Y.; Orr, A. A.; Makam, P.; Redko, B.; Haimov, E.; Wang, Y.; Shimon, L. J. W.; Rencus‐Lazar, S.; Ju, M.; et al. Self‐Assembled Peptide Nano‐Superstructure towards Enzyme Mimicking Hydrolysis. Angew. Chemie Int. Ed. 2021, 60, 17164-17170 (Impact Factor: 16.82)

• Tao, K.; Orr, A. A.; Hu, W.; Makam, P.; Zhang, J.; Geng, Q.; Li, B.; Jakubowski, J. M.; Wang, Y.; Tamamis, P.; et al. EDTA-Mimicking Amino Acid–Metal Ion Coordination for Multifunctional Packings. J. Mater. Chem. A 2021, 9, 20385-20394 (Impact Factor: 14.51)

• Arnon, Z. A.; Kreiser, T.; Yakimov, B.; Brown, N.; Aizen, R.; Shaham-Niv, S.; Makam, P.; Qaisrani, M. N.; Poli, E.; Ruggiero, A.; et al. On-off Transition and Ultrafast Decay of Amino Acid Luminescence Driven by Modulation of Supramolecular Packing. iScience 2021, 24 (7), 102695 (Impact Factor: 5.74) 

• Kavitha, B. S.; Sridevi, S.; Makam, P.; Ghosh, D; Govindraju, T.; Asokan, S.; and Sood, A. K.; Highly Sensitive and Rapid Detection of Mercury in water Using Functionalized Etched Fiber Bragg Grating Sensors. Sens. Actuators B Chem. 2021, 333, 129550. (Impact Factor: 9.22).

• Mondal, A. K.; Brown, N.; Mishra, S.; Makam, P.; Wing, D.; Gilead, S.; Wiesenfeld, Y.; Leitus, G.; Shimon, L. J. W.; Carmieli, R.; et al. Long-Range Spin-Selective Transport in Chiral Metal–Organic Crystals with Temperature-Activated Magnetization. ACS Nano 2020, 14 (12), 16624–16633 (Impact Factor: 15.88).

• Ji, W.; Yuan, C.; Chakraborty, P.; Makam, P.; Bera, S.; Rencus-Lazar, S.; Li, J.; Yan, X.; Gazit, E. Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials. ACS Nano 2020, 14, 7181–7190 (Impact Factor: 18.02).

• Tao, K.; Chen, Y.; Orr, A. A.; Tian, Z.; Makam, P.; Gilead, S.; Si, M.; Rencus‐Lazar, S.; Qu, S.; Zhang, M.; et al. Enhanced Fluorescence for Bioassembly by Environment‐Switching Doping of Metal Ions. Adv. Funct. Mater. 2020, 30 (10), 1909614 (Impact Factor: 19.92).

• Zaguri, D.; Shaham-Niv, S.; Chakraborty, P.; Arnon, Z.; Makam, P.; Bera, S.; Rencus-Lazar, S.; Stoddart, P. R.; Gazit, E.; Reynolds, N. P. Nanomechanical Properties and Phase Behavior of Phenylalanine Amyloid Ribbon Assemblies and Amorphous Self-Healing Hydrogels. ACS Appl. Mater. Interfaces 2020, 12, 21992–22001 (Impact Factor: 10.38).

• Donnell, J. O.; Guerin, S.; Makam, P.; Cazade, P. A.; Haq, E. U.; Tao, K.; Gazit, E.; Silien, C; Soulimane, T.; Thompson, D; Tofail, S. A.; Atomistic-Benchmarking Towards a Protocol Development for Rapid Quantitative Metrology of Piezoelectric Biomolecular Materials. Appl. Mater. Today 2020, 21, 100818 (Impact Factor: 8.66).

• Chen, Y.; Tao, K.; Ji, W.; Makam, P.; Rencus-Lazar, S.; Gazit, E. Self-Assembly of Cyclic Dipeptides: Platforms for Functional Materials. Protein Pept. Lett. 2020, 27. 688-697 (Impact Factor: 1.87)

• Makam, P.; Yamijala, S. S. R. K. C., Tao, K.;   Shimon, L. J.W.; Eisenberg, D. S.; Sawaya, M. R.; Wong, B. M.; Gazit, E. Nonproteinaceous Hydrolase Comprised of Phenylalanine Metallo-Supramolecular Amyloid-like Structure. Nat. Catal. 2019, 2, 977-985. (Impact Factor: 40.71).

• Tao, K.; Xue, B.; Li, Q.; Hu, W.; Shimon, L. J. W.; Makam, P.; Si, M.; Yan, X.; Zhang, M.; Cao, Y.; et al. Stable and Optoelectronic Dipeptide Assemblies for Power Harvesting. Mater. Today 2019, 30, 10-16 (Impact Factor: 26.94).

• Makam, P.; Gazit, E. Minimalistic Peptide Supramolecular Co-Assembly: Expanding the Conformational Space for Nanotechnology. Chem. Soc. Rev. 2018, 47 (10), 3406–3420 (Impact Factor: 60.61).

• Tao, K.; Fan, Z.; Sun, L.; Makam, P.; Tian, Z.; Ruegsegger, M.; Shaham-Niv, S.; Hansford, D.; Aizen, R.; Pan, Z.; et al. Quantum Confined Peptide Assemblies with Tunable Visible to Near-Infrared Spectral Range. Nat. Commun. 2018, 9, 3217 (Impact Factor: 17.69).

• Makam, P.; Shilpa, R.; Kandjani, A. E.; Periasamy, S. R.; Sabri, Y. M.; Madhu, C.; Bhargava, S. K.; Govindaraju, T. SERS and Fluorescence-Based Ultrasensitive Detection of Mercury in Water. Biosens. Bioelectron. 2018, 100, 556–564 (Impact Factor: 12.54).

• Madhu, C.^¶; Roy, B.^¶; Makam, P.^¶; Govindaraju, T. Bicomponent β-Sheet Assembly of Dipeptide Fluorophores of Opposite Polarity and Sensitive Detection of Nitro-Explosives. Chem. Commun. 2018, 54, 2280–2283 (Impact Factor: 6.06).

• Ramesh, M.^¶; Makam, P.^¶; Voshavar, C.^¶; Khare, H.; Rajasekhar, K.; Ramakumar, S.; Govindaraju, T. L-Dopa and Dopamine Conjugated Naphthalenediimides Modulate Amyloid β Toxicity. Org. Biomol. Chem. 2018, 16, 7682–7692 (Impact Factor: 3.89).

• Tao, K.; Makam, P.; Aizen, R.; Gazit, E. Self-Assembling Peptide Semiconductors. Science 2017, 358 (6365), eaam9756 (Impact Factor: 63.71).

• Makam, P.; Senanayak, S. P.; Narayan, K. S.; Govindaraju, T. Multi-Stimuli-Responsive Charge-Transfer Hydrogel for Room-Temperature Organic Ferroelectric Thin-Film Devices. J. Am. Chem. Soc. 2016, 138, 8259–8268. (Impact Factor: 16.38).

• Makam, P.; Senanayak, S. P.; Govindaraju, T. Nanoarchitectonics of Small Molecule and DNA for Ultrasensitive Detection of Mercury. ACS Appl. Mater. Interfaces 2016, 8 (44), 30362–30371 (Impact Factor: 10.38).

• Makam, P.; Govindaraju, T. Engineering Molecular Self-Assembly of Perylene Diimide through PH-Responsive Chiroptical Switching. Mol. Syst. Des. Eng. 2016, 1, 202–207 (Impact Factor: 4.92).

• Makam, P.; Khare, H.; Ramakumar, S.; Govindaraju, T. Crystallographic Insight-Guided Nanoarchitectonics and Conductivity Modulation of an n-Type Organic Semiconductor through Peptide Conjugation. Chem. Commun. 2015, 51, 8315–8318. (Impact Factor: 6.06).

• Makam, P.; Govindaraju, T. Bioinspired Nanoarchitectonics of Naphthalene Diimide to Access 2D Sheets of Tunable Size, Shape, and Optoelectronic Properties. J. Inorg. Organomet. Polym. Mater. 2015, 25, 293–300 (Impact Factor: 3.52).

• Dwivedi, A. K.^¶; Makam, P.^¶; Govindaraju, T. Assembly Modulation of PDI Derivative as a Supramolecular Fluorescence Switching Probe for Detection of Cationic Surfactant and Metal Ions in Aqueous Media. ACS Appl. Mater. Interfaces 2014, 6, 21369–21379 (Impact Factor: 10.38).

• Makam, P.; Khare, H.; Ramakumar, S.; Govindaraju, T. Biomimetic Molecular Organization of Naphthalene Diimide in the Solid State: Tunable (Chiro-) Optical, Viscoelastic and Nanoscale Properties. RSC Adv. 2014, 4, 20154–20163 (Impact Factor: 4.04).

• Makam, P.; Govindaraju, T. Green-Fluorescent Naphthalene Diimide: Conducting Layered Hierarchical 2D Nanosheets and Reversible Probe for Detection of Aromatic Solvents. RSC Adv. 2013, 3, 11459 (Impact Factor: 4.04).

• Makam, P.; Avinash, M. B.; Govindaraju, T. Chiral Transcription and Retentive Helical Memory: Probing Peptide Auxiliaries Appended with Naphthalenediimides for Their One-Dimensional Molecular Organization. Chem. Eur. J. 2012, 18, 4818–4822 (Impact Factor: 5.02). This work is highlighted as Inside Cover Picture.

• Maitra, U.; Makam, P.; Govindaraju, T. Covalent Crosslinking of Carbon Nanostructures. J. Chem. Sci. 2012, 124 (Impact Factor: 2.15).

• Govindaraju, T.; Makam, P.; Jayaramulu, K.; Jaipuria, G.; Atreya, H. S. Spontaneous Self-Assembly of Designed Cyclic Dipeptide (Phg-Phg) into Two-Dimensional Nano- and Mesosheets. Supramol. Chem. 2011, 23, 487–492 (Impact Factor: 2.23).

^* Corresponding author
^¶ Equal contribution
 

• E Gazit, K Tao, Y Chen, S Gilead, S Lazar, P Makam (2021). Quantum confined peptide assemblies and uses thereof  (U.S. Patent App. 17/467,297). U.S. Patent and Trademark

• T Govindaraju, MB Avinash, M Pandeeswar (2016). Self assembly of naphthalene diimide derivatives and process thereof (U.S. Patent No. 9, 230,708). U.S. Patent and Trademark