EDUCATION

Ph.D. (Major-Medicinal Chemistry)   Dept. of Pharmaceutical Sciences,     Wayne State University, Detroit, MI,USA        Sep.2009-Dec.2013      
(Minor Organic Chemistry)                                           
Master of Pharmacy      Institute of Technology, Dept. of Pharmaceutics,         Aug.2005-Aug.2007   
(Pharm. Chem.,GPA = 8.3/10)     Banaras Hindu University, Varanasi, India (Course work)
                                                 Central Drug Research Institute, Lucknow (Project work)
RESEARCH EXPERIENCE
Assistant Professor, Indian Insitute of Technolgoy (BHU), Varansi, India   Feb. 2016 to till date
Visiting Research Sceintist, Brandeis University,                                         Feb. 2016 to Feb. 2017
Dept. of Biology, Waltham, USA
Postdoctoral Research Associate                                                               Feb.2014 to Jan. 2016
Supervisor: Dr. Lizbeth Hedstrom (Dept. of Chemistry and Biology, Brandeis University, USA)
          “Repurposing IMPDH inhibitors (Design, Synthesis and Biological Evaluation) to treat microbial infection”
Graduate Studies (PhD)                                                                                   Sept.2009-Dec.2013    
Supervisor: Dr. Aloke K Dutta 
Dept. of Pharmaceutical Sciences, Wayne State University, USA
“Development of multifunctional drugs for the symptomatic and neuroprotective treatment of Parkinson’s disease (PD).”
Master of Pharmacy                                                                                       June 2006-March 2007
Supervisors: Dr. A K Saxena (CDRI, India) and Dr. SK Singh IT(BHU)
“Synthesis of octahydropyrazinopyridoindoles as biodynamic agents and QSAR studies on 3-aminopyrazole derivatives as anticancer agents”

COURESER TAUGHT :  1. Undergraduate level:  Bioorganic and Medicinal Chemistry, Basic of Pharmaceutical Sciences, Medicinal chemistry, Advances instrumental analysis

1.  Postgraduate level: 1. Advances in Drug Synthesis 2. Advanced medicinal chemistry
2. PhD level: Advanced bioanalytical techniques                   

Departmental activities: Member of DPGC, Establishment of tinkering laboratory, Institute  level project submission form the department of worth  Rs 1.0 crore and member of institute library committee. Member course revision committee
Student Supervision: PhD Research scholar (one ongoing), Master Thesis (4 completed, 2 ongoing),  IDD (One ongoing)
Institute Level Activities: NMR handling at Central instrument facility. Member of institute library committee. Member of the project  purchase committee. 
 

Area of Interest 
1. Development of Novel Naturally Inspired Neuroproective Therapies and Imaging Agents for Alzheimer Disease.
2. Development of Imaging agents/probes for the treatment of Cancer. 
3. Design and synthesis of Novel FtsZ inhibitors as antimicrobial agents.

Publications:  orchid ID https://orcid.org/0000-0002-8003-5566​

1. Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid β and Tau aggregates in Alzheimer’s Disease (Perspective article in J. of Medicinal Chemistry, ACS, Accepted) Rai, Himanshu; Gupta, Sarika; Kumar, Saroj; Yang, Jian; Singh, Sushil; Ran, Chongzhao* ; Modi, Gyan*
2. Multi-component Synthesis of S-Benzyl Dithiocarbamates from para-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer’s Disease, VENKATESH, RAPELLY; Shankar, Gauri ; Narayanan, Aswathi; Modi, Gyan; Sabiah, Shahulhameed; Kandasamy, Jeyakumar. Accepted in J of Organic Chemistry, ACS.
3. Exploration of Neuroprotective Properties of Naturally Inspired Multifunctional Molecule (F24) Against Oxidative Stress and Amyloid β Induced Neurotoxicity in Alzheimer's Disease Models. ACS Chemical Neuroscience, Dec., 2021
4. Further SAR Studies on Natural Template Based Neuroprotective Molecules to Identify Potent Multifunctional Molecules for the Management of Alzheimer’s Disease., Bioorganic and medicinal chemistry, 2021.
5. Essential but not Vulnerable: Structure-guided design of inosine 5’-monophosphatedehydrogenase (IMPDH) inhibitors for Staphylococcus aureus infections.Gyan Modi, Gary M. Marqus, Mohana Rao Vippila, Deviprasad R. Gollapalli, Youngchang Kim, Adhar C Manna, Shibin Chacko, Natalia Maltseva, Xingyou Wang, Ryan T. Cullinane, Yubo Zhang, Judy L. M. Kotler, Petr Kuzmic, Minjia Zhang, Ann P. Lawson,¹ Andrzej Joachimiak, Ambrose Cheung, Barry B. Snider, David M. Rothstein, Gregory D. Cuny and Lizbeth Hedstrom, ACS Infectious disease, 2021.
6. Identification of high affinity and low molecular alternatives of boceprevir against SARS-CoV-2 main protease: a virtual screening approach. Subhomoi Borkotoky  , Manidipa Banerjee  , Gyan Prakash Modi  and Vikash Kumar Dubey  *,  (Accepted for the publications Chemical Physics Letter, I.F. 2.02) 
7. A Review on Ferulic Acid and Analogs Based Scaffolds for the Management of Alzheimer’s Disease  Yash Pal Singh,^a,1 Himanshu Rai,^a,1 Gourav Singh,^a Gireesh Kumar Singh,^b Sunil Mishra,^a  Saroj Kumar, S Srikrishna,^c Gyan Modi ^a* (Accepted for the publications European J of Medicinal Chemistry, I.F. 5.56) 
8. Molecular docking, binding mode analysis, molecular dynamics, and prediction of ADMET/Toxicity properties of selective potential antiviral agents against SARS-CoV-2 main protease: An effort towards drug repurposing to combat COVID-19", Himanshu Rai¹. Atanu Barik¹. Yash Pal Singh¹. Akhil Suresh². Lovejit Singh¹. Gourav Singh¹. Usha Yogendra Nayak².  Vikash Kumar Dubey³. Gyan Modi^1* (Accepted for the publicationsin Molecular Diversity, IF 2.2)
9. The Evolving Landscape of Exosomes in Neurodegenerative diseases
   Salivary Exosomes, a promising candidate for early diagnosis, Simran Rastogi, Vaibhav Sharma, Prahalad Singh Bharti, Komal Rani, Gyan Modi, Fredrik Nikolajeff *, Saroj Kumar * (Invited review, accepted for the publication in International Journal of Molecular Sciences, I.F. 4.55)
10. A novel approach to correlate the salivary exosomes and their protein cargo in the progression of cognitive impairment into Alzheimer's disease. KOMAL RANI; SIMRAN RASTOGI; POORVI VISHWAKARMA; PRAHALAD S BHARTI; VAIBHAV SHARMA; GYAN P MODI; VENUGOPALAN Y VISHNU; PRASHUN CHATTERJEE; APARAJIIT B DEY; FREDRIK NIKOLAJEEF;​ (Accepted for publication in J of  Neuroscience methods, I.F. 2.2)
11. Drug repurposing for Alzheimer’s disease: in silico and in vitro investigation of FDAapproved drugs as acetylcholinesterase inhibitors. Navneet Kumar , Anuj Gahlawat  , Rajaram Naresh Kumar, Yash Pal Singh , Gyan Modi,  Prabha Garg  (Accepted for publications in J of bimolecular structure and dynamics)
12. Molecular docking and binding mode analysis of selected FDA approved drugs against COVID-19 selected key protein targets: An effort towards drug repurposing to identify the combination therapy to combat COVID-19
    Atanu Barik, Geeta Rai, Gyan Modi,  https://arxiv.org/abs/2004.06447
13. Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease.   European Journal of Medicinal Chemistry (IF. 5.56)  Yash Pal Singh, Gullanki Naga Venkata Charan Tej, Amruta Pandey, Khushbu Priya, Pankaj Pandey, Gauri Shankar Prasanta Kumar Nayak,Geeta Rai, Amar G. Chittiboyina, Robert J Doerksen, Swati Vishwakarma, Gyan Modi.
14. A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer's and Parkinson's diseases. Yash Pal, Amruta Pandey, Swati Vishwkarma, Gyan Modi (Under minor revision, Mol diversity, Springer)
15. Piperazine-2,5-diones as a dual inhibitor of Acetylcholine esterase and Matrix metalloproteinase (MMP-2) for Alzheimer disease. Devendra Kumar, Sukesh K. Gupta, Ankit Ganeshpurkar, Gopichand Gutti, Krishnamurthy Sairam, Gyan Modi, Sushil Kumar Singh (Accepted for Publication in  European J of Med. Chem.)
16. Biomolecular basis of Matrix Metallo Protenase -9 (MMP-9) activity.  Rayala Swetha, Chandrim Gayen,  Devendra Kumar,  Tryambak Deo Singh, Gyan Modi, Sushil  K Singh (Accepted for Publication in Furture Medicinal Chemistry)
17. Secreatase Inhibitors for The Tretatment of Alzheimer’s Disease: Long Road ahead. Devendra Kumar, Ankit Ganeshpurkar, Dileep Kumar, Gyan Modi, Sanjev Kumar, Sushil K singh.  (Accepted for Publication in  European J of Med. Chem.)
18. Alpha-synuclein aggregation modulation: An emerging approach for the treatment of Parkinson’s disease. Sushil K. Singh, Aloke Dutta,  and Gyan Modi*. Invited review in Furture medicinal chemistry. Furture Medicinal Chemistry, 2017, 9(10). 1039-1053
19. Inhibition of IMPDH from Bacillus anthracis: Mechanism revealed by pre-steady state kinetics. Yang Wei, Petr Kuzmic, Runhan Yu, Gyan Modi and Lizbeth Hedstrom (Journal of Biochemistry, 2016, 55 (37), 5279-88)
20. Inhibitors of IMPDH from mycobacterium tuberculosis with antitubercular activity. Magdalena Makowska-Grzyska, Youngchang Kim, Suresh Kumar Gorla, Yang Wei, Kavitha Mandapati, Minjia Zhang, Natalia Maltseva, Gyan Modi, Helena I. Boshoff, Minyi Gu, Courtney Aldrich, Gregory D. Cuny, Lizbeth Hedstrom and Andrzej Joachimiak. (Plos One, Pubished on Oct. 6, 2015, DOI:10.1371/journal.pone.0138976)
21. Dopamine D3 agonists in the treatment of Parkinson’s disease. Banibrata Das, Gyan Modi, Aloke Dutta (Invited review in Current Topics in Medicinal Chemistry, 2015,15, 10, 908-926)
22. Understanding the structural requirements of hybrid (S)-6-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol and its analogs as D2/D3 receptor ligands: A three-dimensional quantitative structure-activity relationship (3D QSAR) investigation. Gyan Modi, Horrick Sharma, Prashant Kharkar*, Aloke K. Dutta*, (MedChemComm, 2014, 5, 1384-1399)
23. Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: Modulation of toxicity of alpha synuclein aggregates. Gyan Modi, Chandrashekhar Voshavar, Sanjib Gogoi, Mrudang Shah, Tamara Antonio, Maarten E.A. Reith, Aloke K. Dutta (ACS Chemical Neuroscience, 2014, 5, 700-717).
24. Structural modifications of neuroprotective anti-Parkinsonian (-)-N⁶-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): An effort towards the improvement of brain penetration property of the parent molecule. Gyan Modi, Tamara Antonio, Maarten Reith, Aloke Dutta. (J. Med. Chem., 2014, 57, 1557-1572).
25. Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. Sanjib Gogoi, Swati Biswas, Gyan Modi, Tamara Antonio, Maarten Reith,  Aloke K. Dutta. (Medicinal Chemistry Letter, 2012, 3(12), 991-996)
26. Further structure activity relationship studies on 4-((((3S,6S)- 6-Benzhydryltetrahydro-2H-pyran-3- yl)amino)methyl)phenol: Identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.  Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, Mark Johnson, Gyan Modi, Solav Ali, Juan Zhen, Maarten Reith, and Aloke Dutta. (J. Med. Chem., 2011, 54, 2924–2932)

BOOK CHAPTER

1. Targeting purine biosynthesis for antibacterial drug design. Gyan Modi, Shibin Chacko and Lizbeth Hedstrom.  (RSC, Antibiotic drug discovery)

PATENTS FILLED: 1.  IMPDH-targeted antibiotics, Michael J. Pepi, Lizbeth K. Hedstrom, Deviprasad R. Gollapalli, Shibin Chacko, Gyan Modi, and Suresh Kumar, Filing Date:  April 26, 2018, FH Reference No.:  BUG-07360 (22247-07360)
2. Compounds and methods for the treating chronic microbial infecstions, Lizbeth K. Hedstrom, Deviprasad R. Gollapalli, Suresh Kumar and Gyan Modi, Filing Date:  November 30, 2018,
U.S. Application No. 62/773,703
3.A Pharmaceutical composition of sulfonamide derivaies for the treatment of Alzheimer’s disease. (Indian Patent File 201711041328)
4.Development of multifunctional hybrid 3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid and substituted amine/piperazine  derivatives for the treatment of neurodegenerative disorders   Gyan Modi, Yash Pal Singh, and Amruta Pandey (Patent Application # 201911000362)
5. A NOVEL ANTI-COAGULANT FORMULATION AND A METHOD OF PREPARATION THEREOF, Sairam Krishnamurthy, Pankaj Palliwal, Gopi Chand, SK Singh, Gyan Modi (201911012094)
6.      ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND USES THEREOF, Michael J. Pepi, Lizbeth K. Hedstrom, Deviprasad R. Gollapalli, Shibin Chacko, Gyan Modi, Suresh Kumar and Greg Cuny, PCT/US19/29338 (Filled on April 26, 2019)
7. COMPOUNDS AND METHODS FOR TREATING CHRONIC MICROBIAL INFECTIONS, Lizbeth K. Hedstrom, Deviprasad R. Gollapalli, Gregory D. Cuny, Suresh K. Gorla, Gyan Modi, and Mohana R Vippila, Filing Date:  November 25, 2019, FH Reference No.:  PCT/US19/62946
8. A MULTIFUNCTIONAL DIARYLUREA-HYDROXYAMIDINE BASED COMPOUND FOR TREATMENT OF ALZHEIMER DISEASE, gyan modi, Yash Pal,  C. Praveen Kumar, Meenu Yadav, Gauri Shankar, Gourav Singh, Saroj Kumar, S Srikrishna. TEMP/E-1/1680/2021-DEL, 12 Jan, 2021.
9. An Imaging Probe for Detection of Key Biomarkers in Alzheimer Disease (Patent ICMR-202211027649), Gyan Modi, Himanshu Rai, Saroj Kumar, Rishab Singh, Sarika Gupta, Sairam Krishnamurthy, Gauri Shankar,  S Srikrishna, Brijesh Singh
 

CURRENT RESEARCH PROJECTS
Development of exosome based drug delivery system for naturally inspired novel multifunctional neuroprotective molecules and their biological evaluation in Alzheimer’s disease models (ICMR-EMR-2021-Technically approved, PI, Fund INR-55,59,246   
Natural Template Based Novel Neuroprotective Molecules for The Management of Alzheimer’s Disease (SERB-Core Research Grant (CRG-2019/003490), PI, Fund INR 37,20,280,
Development of novel near infrared fluorescence imaging probes for detecting amyloid beta species in eyes of Alzheimer’s disease animal model,  PI, Extramural grant, ICMR Project code: 2019-3088, Fund INR 37,00,000) .
"Design and Development of Selective Acetylcholine Esterase Inhibitors for the Treatment of Alzheimer’s Disease". IIT(BHU) Send Money, Fund INR 10,00,000 
Re-purposing of approved drugs from DrugBank database for possible treatment for COVID-19 by targeting SARS-CoV-2main protease (Role Co-PI, SERB-CRG Special call)
Role: Co-PI, PI Prof. Vikash Kumar Dubey, Dept of Biocehmcail Engineering, IIT (BHU)
Design, Synthesis and Biological Evaluation of O- and C-Derivatives of Phenylethanoid Glycosides as a Multi-targeting Neuroprotective Disease Modifying Agents for Alzheimer's Disease Role Co-PI, (SERB-CRG/2020/5542, Cost Rs. ~47,00,000) PI Dr. Jeyakumar Kandasamay, Dept of Chemistry, IIT (BHU)

Reserach Projecst to the students as Supervisor

Consequences of differentially expressed miRNAs after synergistic chemopreventive effects of Boesenbergia pandurata extracts and G-111 compound in breast cancer cells under hypoxia (ICMR-RA- to Dr. Nishant Rana, 2021-15006, technically approved)
Development of exosome based drug delivery system for naturally inspired novel multifunctional neuroprotective molecules and their biological evaluation in Alzheimer’s disease models (ICMR-SRF to Mr. Gauri Shankar-2021-9209, technically approved)
“Development of novel aggregation-induced-emission (AIE) active fluorescence imaging probes to detect the pathogenic biomarkers of Alzheimer’s disease.” (ICMR-SRF to Mr. Himanshu Rai-2021-9209, technically approved)
“Design, synthesis, and biological evaluation of Caffeic acid-based naturally inspired novel neuroprotective molecules for the treatment of Alzheimer's disease” (DST-Inspire- Mr. Sunil Kumar)
Development of Green & Sustainable C-H Functionalization Approaches: Total Synthesis of Medicinally Active Molecules and Their Biological Evaluation. (Approved  ICMR RA fellow,  and transferred to ICT, Mumbai)
 

1. Rotatory Evaporator
2. Ultra Low Temperature Reaction-Bath with Inbuilt MagneticStirrer facility.
3.  ThermoMixer C, basic device 
4. SmartBlock 1.5mL, thermoblock for 24 tubes 1.5 mL
5. ThermoTop with condens.protect technology for ThermoMixer C,
6.SmartBlock plates, thermoblock for plates and deepwell plates incl. Lid
7. Deep Freezer (-80 C)
8. CO2 incubator
9. Biosafety cabinet
10. Plate reader (absorption based)
11. Inverted microscope

Sarika Gupta, National Institute of Immunology, New Delhi
Saroj Kumar, All India Institute of Medical Sciences, New Delhi
Geeat Rai, Molecular and Human Genetics, BHU

Former PhD  Students
1. Yash  Pal Singh  (December, 2021) Current Position: Postdoctoral Fellow in the laboratory of Prof. Linsberg Iris, University of Maryland School of Medicine, Baltimore, USA. 
 Yash was also selected for DBT-RA position with Prof.T Govindaraju, JNCASR. 

Current PhD Students
  1. Gourav Singh 
   2. Gauri Shankar
  3. Himanshu Rai
  ​4. Sunil Kumar 
  5. Rakesh Gautam

Current PG ( IDD and M.Pharm) students
1. Sourabh Bhatia
2. Syedajijurrahaman

Former PG,(M.Pharm) and IDD Students

1. Chandrim Gayen 2016-17, Current position:
2. Ragini Gupta-2016-17, Current position:
3. Amruta Pandey-2017-18, Current position:
4. Swati Vishwakarma-2017-18, Current position:
5. Meenu Yadav
6. C. Praveen Kumar
7. Prince Kumar- IDD 
8. Manish Kumar- IDD 
9. Atanu Barik
10. Lovejiit Singh

Former UG Students
1. Deepak Yadav
2. Prem Chopra 
3. Abhishek Kumar Singh
 

      Selected as Participant to attend Young Investigator Meeting (YIM-2019) Sponsored by Indiabioscience, Division of DBT, india
      SERB International Travel Support-2018 for EMBO workshop
      Outstanding Scientist in Medicinal Chemistry, Venus International Foundation, 2017
      NIH  Postdoctoral fellowship 2014-2016
      Frank O. Taylor award, In reorganization of outstanding scholarship and academic performance. dept. of pharm. sci., wayne state university.
      Travel Award, Graduate school and Dept. of Pharm. Sci,, Wayne state university.
      Graduate Research Assistantship for PhD programe (2009-2013), Wayne state university.
     Received the grant from the university grant commission (UGC), India for Master of Pharmacy.